PETHEDINE IN COMBINATION WITH KETAMINE TO ABOLISH ITS POSTOPERATIVE HALLUCINATION EFFECT

Abstract

Background: Ketamine is a potent analgesic and sedative and its analgesic effect persists after its sedation effect(2), but still there is controversy about using ketamine as analgesic due to its psychomimetic adverse effects like hallucinations or nightmares
Objectives: the target is to evaluate the effect of pethedine in combination with ketamine to decrease post sedation side effects of ketamine like hallucinations
Patients and methods: 150 patients divided into 3 groups,group A 50 patients received ketamine by dose of 1mg/kg.group B patients received ketamine by same dose in combination with midazolam by dose of 0.05mg/kg and group C received ketamine by same dose with pethedine by dose of 0.5mg/kg.
Results: the postoperative hallucinations were significantly higher in group A (16 patients, 32%) compared with groups B and C. Also, hallucination was significantly higher in group B (7 patients, 14%) compared to group C (3 patients, 6%)
Conclusion: pethedine is better than midazolam to control postoperative hallucinations of ketamine when used in combination for sedation in minor operations
Keywords: ketamine,pethedine,midazolam,hallucinations.