STUDY OF SERUM ESTROGEN AND TESTOSTERONE LEVELS IN ADULT AND ELDERELY MEN WITH TYPE 2 DIABETES MELLITUS

Abstract

Objective: Measurement of serum levels of estrogen and testosterone in adult and elderly men,
Evaluation of the relationship between these two hormones and major cardiovascular risk factors ;
Their relation with retinopathy as an index of diabetic microangiopathy and myocardial infarction as
an index of diabetic macroangiopathy was also measured and Studying of the effect of normalization
of glycosylated hemoglobin A1c (HbA1c)and plasma lipids on serum levels of estrogen and testosterone
by re-measuring their level after normalization.
Research Design and Methods: We studied from august 2008 to august 2010, The study population
included 150 subjects, I)120 patients with type 2 diabetes, were selected so that both adult and elderly
men as two main groups;1&2 each (n=60). Each group of patients included four subgroups each one
(n=15): Subgroup A: well controlled non complicated diabetics, Subgroup B: poorly controlled non
complicated diabetics, Subgroup C: patients with diabetic retinopathy as an index of diabetic
microangiopathy complications Subgroup D: patients with myocardial infarction as an index of
diabetic macroangiopathy complications. II) The study also included two groups of healthy subjects,
each (n=15), as control groups. Each one was matched with the age of its corresponding group of
patients (adult and elderly).
Results: S.free testosterone is statistically significant predictors of CVD (B ±SE =0.116 ±0.062
,P=0.011), statistically significantly positive correlation between S. estradiol and HDL(r= +0.33,P<
0.o1 ), statistically significantly negative correlation between S. estradiol and TC(r= -0.23,P< 0.o5 ),
statistically significantly negative correlation between serum free testosterone and age, BMI , SBP,
DBP, SBP, HbA1C, TC ,LDL and TG, (r= - 0.21, - 0.33, - 0.72, - 0.67, - 0.59, - 0.79, - 0.75, - 0.77
respectively ,P< 0.o1, P< 0.oo1, P< 0.oo1,P < 0.oo1, P< 0.oo1 ,P< 0.oo1 ) statistically significantly
positive correlation between serum free testosterone and HDL (r=+ 0.78, P< 0.oo1), while there was
no significant correlation between serum free testosterone and S.estradiol.
Conclusions: In type 2 diabetic men , serum free testosterone was significantly associated with
cardiovascular disease ,while there was no association of s.estradiol with CVD and both of them
were not associated with diabetic retinopathy.
Keywords: serum estrogen, serum free testosterone, cardiovascular disease , elderly.