DICLOPHENAC SODIUM FOR MANAGEMENT OF PAIN DURING PROPOFOL INJECTION

Abstract

Background: Propofol pain during injection has an incidence range between 28%-91% in adult paients, even small doses for sedation is associated with pain during injection. Objectives: To evaluate diclophenac sodium by dose of 25 mg by direct intravenous injection for reduction of propofol induced pain during injection. Patients and methods: 150 patients scheduled for elective surgical procedures divided into three groups, group A "placebo group", group B "lidocaine group" receiving 1 mg/kg lidocaine diluted to 5 ml normal saline and group C receiving 25 mg diclophenac sodium diluted to 5 ml saline. All patients aged from 20 to 60 years and were ASAI and II. Results: 42 patients (84%) received diclophenac sodium had no pain during propofol injection comparred with 41 patients (82%) received lidocaine and only 2 patients in placebo group. Also one patient had severe pain during injection in diclophenac group but no patients in lidocaine group compared with 35 patients (70%) in placebo group. Conclusion: Diclophenac sodium by dose of 25 mg can be used as pretreatment for reduction of propofol induced pain and it was comparable with lidocaine by dose of 1 mg/kg.
Keywords: diclophenac sodium, lidocaine propofol, pain