THERAPEUTIC EFFECACY OF OZONE AND LOW LEVEL LASER IN TREATMENT OF DIABETIC FOOT ULCERS

Abstract

Back ground : Diabetes Mellitus is a syndrome characterized by disordered metabolism and high
blood sugar (hyperglycaemia) resulting from either low levels of the insulin hormone or from
abnormal resistance of cells to insulin's effects coupled with inadequate levels of insulin secretion to
compensate.In wound care, ozone is considered as an anti-bacterial, anti-fungal and anti-viral agent.
During the treatment an ozone generator produces ozone into a bag that surrounds the patient’s leg
ulcer. The treatment is administered three times per week for several weeks; there are many other
methods of ozone administration as major and minor autohaemotherapy, rectal insufflations, direct
intramuscular injection and intrarticular injection.Laser irradiation was able to significantly enhance
the healing of diabetic wounds. And has a stimulatory effect on the fibroblast cells of the diabetic
wounds. Materials and methods: It is a randomized controlled clinical trial. The number of
patients was 60 patients. The calculation of the size of the ulcer was done by using the graph papers
to document the ulcer-s perpendicular linear dimensions (typically in centimeters using graph paper);
the maximum distance is length and perpendicular distance is width. And measure the progress of
healing every month and record the percent of healing. The patients were randomized to 3 different
groups of treatment (I treated by laser, II treated by ozone, and III treated by surgical debridement
only). Results: after treatment for 3 months by ozone and laser and surgical debridement many cases
achieve complete healing at the laser and ozone groups in the second and third month but not in the
third group Conclusion: Low-level laser therapy and ozone therapy could be a safe and effective
method for treatment of diabetic foot ulcers. Clinical trials with higher sample size are proposed to
more evaluate the efficacy of low-level laser therapy and ozone in treatment of this type of wounds.
Key words: ozone therapy, low level laser therapy, diabetic foot ulcer.