THE EFFECT OF HEPATITIS C VIRUS INFECTION ON INSULIN RESISTANCE IN CHRONIC HEMODIALYSIS PATIENTS

Abstract

Hepatitis C virus infection has strong relationship with insulin resistance in general population. Insulin resistance increases risk of cardiovascular events in chronic kidney disease patients.This work is intended to study the interrelation between Hepatitis C virus infection and insulin resistance among end stage renal disease patients on regular hemodialysis.
Methods: It included a total number of 90 subjects. They were divided into two groups: Group 1 (45 subjects Hepatitis C viruspositivepatientson regular hemodialysis), Group 2 (45 subjects Hepatitis C virusnegative patients on regular hemodialysis).All patients included in this study were subjected to the following: Full clinical assessment,Complete blood picture, alanine aminotransferase, aspartate aminotransferase, creatinine, blood urea, fasting plasma glucose, Coagulation profile, serum calcium, serum phosphorus, serum parathyroid hormone, Hepatitis C virusantibodies, human immunodeficiency virus antibodies, hepatitis surface antigen, fasting serum insulin and fasting serum C-peptide.
Results: Our study reported that no statically significant difference in Homeostatic model assessment of insulin resistance between the two studied groups. Homeostatic model assessment of insulin resistance has significant correlation to age, weight, body mass index,serum parathyroid hormone, serum creatinine, urea reduction ratio and serum ferritin.
Conclusion: We couldn’t detect any strong correlation between Hepatitis C virus seropositivity and insulin resistance in hemodialysis patients, but we detected strong relationship of insulin resistance to age, weight, body mass index, serum parathyroid hormone, serum creatinine, urea reduction ratio and serum ferritin in hemodialysis patients.
Keywords: Insulin resistance, Hepat