CLINICOPATHOLOGIC CORRELATION OF CALRETININ EXPRESSION IN BREAST CANCER

Mayada S Farrag, Amro A El-karef, Maha M Amin, Nagwa M Helal, Omar F Ali

Abstract


ABSTRACT

Introduction and aims: It was found that calretinin is expressed in many tumors other than mesothelioma including breast carcinoma. We aim to assess calretinin expression in correlation with other clinicopathological parameters of breast carcinoma.

Methods: By using tissue microarrays, 225 breast cancer cases were immunostained for calretinin, estrogen receptors, progesterone receptors, and HER2.

Results: Tumors of high grade showed high calretinin expression (P<.0001). High loco-regional recurrence was also associated with high expression of calretinin (P=.005). Negative ER showed significant association with high calretinin expression (P= .005). Negative PR, positive Her2neu showed also high significant association with high calretinin expression (P< .001).

Conclusion: Calretinin expression is high in high grade hormone negative tumors 

Keywords: Calretinin, breast carcinoma.


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