CLINICOPATHOLOGICAL SIGNIFICANCE AND CORRELATION OF SURVIVIN, HER2 AND BCL2 EXPRESSION IN BREAST CARCINOMA

Abeer M. Abdelbary, Walid S. Elsayed, Abdelmonem A. Hegazy

Abstract


ABSTRACT
Background: Breast cancer is the most common cancer among females worldwide, accounting more than one third of the total percentage of all cancers in Egypt. Objective: This study aimed to correlate the immunohistochemical expression of survivin, HER2 and BCL2 with the clinicopathological variables in breast carcinoma to clarify the effect of marker expression on tumor behavior and prognosis. Methods: Immunohistochemical expressions of the three biomarkers were evaluated in 65 cases of breast carcinoma and the harvested data were correlated with clinicopathological parameters. Results: The specimens were 55 infiltrating duct carcinoma (IDC) and 10 cases of ductal carcinoma in situ (DCIS). Survivin was expressed in 3 cases (30%) of DCIS and in 40 cases (72.7%) of IDC. There was a positive significant association between survivin expression and tumor size. Also, there was a significant association between survivin expression and histological grade, tumor stage and LN metastases. Significant relationship between survivin expression and both estrogen receptor negative and progesterone receptor negative hormonal status was noticed. HER2 was expressed in 5 cases (50%) of DCIS and in 20 cases (36.4%) of IDC. There was a positive significant association between HER2expression and tumor size, tumor stage and LN metastases. The expression of HER-2 had a significant negative correlation with a status of estrogen (ER) and progesterone receptors (PR). BCL2 was expressed in 7 cases 70% of DCIS and in 42 cases (76.3%) of IDC. There was increased BCL2 expression in small sized-tumors. Also there is a highly significant association between BCL2expression and grade of tumors. There was no significant association betweenBCl2 expression and stage of tumors and LN metastases. The expression of BCL2 had a significant positive correlation with a status of ER & PR. Conclusion: Both survivin and HER2 are prognostic biomarkers, but BCL2 expression is associated with low grade tumor, small size and positive ER and PR.
Key words: Immunohistochemical; Survivin; HER-2, BCL2; Carcinoma; Breast


Full Text:

Untitled PDF

Refbacks

  • There are currently no refbacks.