EFFECT OF ANTIREFLUX THERAPY ON THE VOICE OUTCOMES OF PHONOMICROSURGERY FOR VOCAL FOLD POLYPS

Abstract

Objective: to study the effect of antireflux therapy in the form of PPI and sodium alginate, on the voice
outcome after phonomicrosurgery of vocal fold polyps. Study Design: All patients with vocal folds polyps
were seen in the outpatient clinic and phoniatric unit of otorhinolaryngology department, Zagazig University
Hospitals in the period from July 2016 to January 2018. Patients were divided into 2 groups one group
received antireflux therapy in the form of proton pump inhibitors (omeprazole 20mg twice daily plus liquid
alginate (gaviscon advance) one table spoonful 10ml 1×3after meal and at bed time. The duration of
treatment was 8 weeks. The other group wasn’t received antireflux therapy postoperative. Results: A total of
24 patients met inclusion criteria and divided into two groups. In the two groups of 12 patients each from our
study there was a statistically significant improvement regarding laryngeal evaluation, grades of dysphonia,
the acoustic and aerodynamic parameters i.e. jitter (p = 0.001), shimmer (p = 0.02) and maximum phonation
time (p = 0.001) and AFF (p = 0.04) in the group in which proton pump inhibitor and gaviscon advance were
taken postoperative (group A) while in group B there is no Statistically significant difference in Average
fundamental frequency.AFF, Jitter, Shimmer (p value above 0.05), but there was statistically significant
difference in HNR (p = 0.05) and Maximal phonation time(MPT) (p value 0.008).
Conclusion: The intake of combination of proton pump inhibitor and gaviscon advance liquid is beneficial
if taken after phonomicrosurgery for vocal fold polyp to overcome the acidic and non acidic components of
the reflux with statistically significant results
Key Words: Voice–Dysphonia–Phonomicrosurgery–Laryngopharyngeal reflux